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Hi Bazotto - I'm trying to remember.
29 across is an anagram, the t in It's being omitted (double use of the last phrase)
40 is a scientific tool, framed by opter
25 is most of a former PM upended
27 is easier if you have solved 46. Think words for eye disorders. GOC is extra
35 minder is extra, the answer is not usually an english word

Bazotto - some more hints

31a First word is def - I can’t remember exactly how the rest works
33a First word is def - anag of operative minus the O, then “sure”
36a First word is def - 4-letter word for landed inside “the” beheaded
3d three defs, though the first two are in the same paragraph in Chambers
30d 2-word def, then A and V followed by anag of D omega, all inside ss
32d 2-word def, then reverse of about (2) and splashes (4)

29: Anagram of ITS AROUND minus the T - Jurassic Park...
31: Cooler=shortened form of refrigerator; anagram of THEN inside; CHILLS=def
33: Sure=YES after anagram of (o)PERATIVE
36: ALIT inside (t)HE
40: Someone choosing=OPTER. Temper=CALM
3: Triple definition
25: The PM is from a long time ago - William ????
27: Anagram of MASH HOSPITAL ignoring the letters given by the answer to 46acr
30: Anagram of A V D OMEGA in SS
32: Reversal of RE + word for splashes
35: REST=LIE inside anagram of RACES