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21a may be wicked but how does it parse please?

Nice crossword with some clever clues.

Hi ganda
21a has 5 alternate letters backwards

Many thanks Chris. We were on the wrong track entirely.

Sorry: chrise

I prefer Chris! I couldn't be that when I joined as there was a pre-existing one.

Noted.

Finished. Had a lot still to do before I started to look at the forum, but various posts helped us to get 11, 21, 1, etc and other answers became doable with crossers.

FOI: 29
LOI: 14 (needed 26 first)
COD: 7, though perhaps it stretches general knowledge unfairly?

I don’t think anyone has mentioned the capitalisation of the “R” in “Rat”. I suspect this is a deliberate nudge towards the intended reference being a proper noun.