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Help please with 23d!
Also cannot find the third 16 letter entry in any crossword finisher... probably not in English?
Got everything else.

Ptobes - 28d is the commonly used name of a real London Hospital - wordplay is half of a 10-letter eye defect backwards.

Wowzah, i wasn't even in the vicinity! Thanks, jbird

lumen - other setters might have said Will's project...

Thanks upsetting, I thought maybe Henry's fourth letter to start...
I have it now. Makes the bottom row even more ridiculous!
Actually also I have the first cell of 25a empty still. No idea how reputed cones into it.

lumen 23d - wordplay is 2 + 1 + 3

Lumen - 25a - the first part of the answer derives from French.

Don't attempt the bottom row until you have the top and middle row. The bottom row is a variant.

Indeed, Mack. Worth remembering Flann O’Brien’s pair of sailors…..

You have me there, Jack. If it's the book I think you're referring to, I'm afraid I haven't read it ... yet. I'll add it to my list.