DFG2, your 8-letter word is significant, but you'll need the theme for context! I didn't bother with the four (not two!)locations until afterwards - they'd have meant nothing even if I'd spotthem them,which I didn't.
The letter pairs, definitions really did help - and as said earlier, those a the start of the clues proved quite revealing.
Think of the letter pairs bit as a mini-clue - 'Malone on vacation' would give ME. and 'So twisted' would give OS. Just examples, not in this puzzle!