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I have a full grid and the five instructions (although I’m unsure about the final word of the 5th). I have no idea how to implement the 4th, the significance of its final word eludes me as does the significance of the title. Any help would be gratefully received.

Snap. I'm at the same place exactly! Help needed.

If you follow the instructions and perform the 2nd instruction with scissors, then do the 3rd instruction, I spotted the solution by looking for vertical groups of 3 that could follow each other. A bit more scissor work as per instruction 4 and hey presto .... Not sure however about the annotation, though if you google the experiment Wikipedia helps.

I have SITE for the final word of the 5th instruction.

I'm puzzled by the annotation, too. Also suspicious of what "site" means exactly. Could there be more to this than meets the eye?

I guess the 'site' means both the building and the city. As the experiment is quite likely apocryphal, a correct 'brief description' might be to question "result of what ?"

I have a full grid and five instructions. I m puzzled by the first one. Can someone confirm it has four words please and whether it requires a grid stare to identify elements?
Thanks in advance

Many thanks, S_Pugh, Meursault, and Durban: I have the experiment, now.

Can anyone please help with 27a? I can't see how it parses and am missing the 4th letter, which is distracting me from the endgame.

Phil535, My interpretation of the first instruction is that it consists of four words plus 2 letters. That's the bit I don't understand. Why is it necessary, especially as the preamble tells us to use all cells in the conversion? If the first instruction is carried out won't there be two cells short?

The last instruction is indeed ambiguous. Meursault's guess is probably right, but the last word of the thematic item is enough on its own as well.

Last year the setter's puzzle on Dante's Inferno had various ambiguities, so the editors had to allow alternative solutions. Is the same going to happen here? And how brief is 'brief'?