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28a I fail, bankrupt, more or less in disgrace (3,4) i?l ?a?e (fail could be fall).
22d Mary produces boy in your novel (3,4) o?r ???y must be our something - perhaps our lady: lad in anagram of your, but can’t parse.

22 Our Lady, Mary (of the Bible). Your and Lad, boy, anagrammed.

Thanks Malone.
The other answer is ill fame - anagram of i fall plus me minus the or.