35a Stroke stopping dense profligate caused distress (10) ... for the grid entry I have S??A?G?DNESS so scraggedness would fit but I guessed at some of those letters!?
21d I have the clue answer but can't see what to replace it with for the grid answer (the clue didn't seem to need a word changing so I'm assuming it's a grid-entry change one)
17d Charge tenor with injurious influence (5) .... for the grid entry I have TR?????