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1a. One twice intervenes in tricky subject concerning an old Catholic (9) --BU--T--.
15a. Huge deal losing tons for a type of shellfish (6) O-TR--.
22d. Senior carrying PC accessory is a travelling salesman abroad (7) -M-US-R.
26d. Support for Diana, opera superstar could be shown thus (5) -RA--.

1a Jebusitic?
15a ostrea
22d s mouse r
26d bra (di)va

Thank you Sudokulover.

8d. Note shops do traditional medicine in South Africa (4) --T-.
12a. Group of cells left warning of an attack (5) -A-RA.

Any help on my 15:48 post? Last two.......

12 Laura, I think - L for left +Aura, warning of an attack (migraine).

8 D. Muti

Thanks Malone!

You're welcome.