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Thanks to earlier responses I am now down to about 10, mostly in the bottom right.

I'm hoping that assistance with one may spur my tired brain into more activity :

53A - Novel, reader admits, open rarely (5, 4, 2, 5)#
?O?R? D??? D? ??R??

I also have two I cannot get despite all the other letters being in place :
22D - Do out stable at last - dig and potter about (8)
?A?B?C?E BARBECUE?
&
28D - Plant expert with tip for gardener (4)
?C?R

Some or, indeed, all of these letters may be wrong.

28 acer

22 Barbecue - (a do outside)

Dig - Barb
Stable at last - E
Potter - Cue (Snooker)

53 notre dame de paris

53 A Novel - anagram - think Quasimodo.

Ta Mamya - barbecue was v. helpful. I'm stuck on one last one: 39 ac. Can you help, please?

Rossim & Mamya

Thanks, you are most kind - I never would have got 53A as I hadn't realized that was the name of the book involving Quasimodo. Obviously reading Les Mis failed to help.

39a Tight lipped person slow to dismiss Republican Party in US. (8)

Tight lipped person - Clam
slow to dismiss Republican - B(r)ake

Clambake - Party in US

Brilliant, Mamya - thanks a lot!