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1 down friends split by it in cains murder (2 words)
?A???A?SI?
2 down one royal editor thoroughly exhausted
?S???P
I feel I must have something wrong and would appreciate some help

Cain + Pals with it inside - ca pital s in?

us ed up

Thank you Ab and Rambler, I can't parse 2 down though?

one royal is 'us' as in 'the royal we'
ed - editor
'up' is given in Bradford's as 'thoroughly' - as I think in the sense 'from the ground up'

I thank you again rambler for your help. I would never have worked that one out.