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OK! After the debacle of RT 5 (see below) I have to accept I'm not as intelligent as I had hoped because I'm stumped on 4 Down "Drug sect - say again" (7) - I have _c_t_s_
It would obviously appear to have "sect" in there but It's fooled me.
I have a hard wall handy against which to bash my cranium when I see the answer!

Ecstasy

Ecstasy being a drug of course and then anagram (again) sect say.

I think I just made up 'again' as an anagram indicator, but that is the way I read it.

Thanks for that - that's it now! - the answer's so flipping obvious I'm gonna turn in my biro and take up gardening - I feel so humiliated!

Don't say that.