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Down to last 4. Can anybody please put me out of my misery? Thanks for any help.

12a. Kill graduate to get estate (6) ?O?A?N
21a. Safe-keeping promised initially with a proviso
(12) ???S?R?????N
16d. He apparently marks his choice wrong! (5) V?T??
20d. Can she go to the country? (A??)

16 Voter - marks with an 'X'

12 Domain - Do MA in

21 P Reservation

P reservation
can Ada?

Great answer Trevor !

Mamya and Trevor, thank you so much for your answers.
Trevor your Can-ADA answer was pure genius.