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Struggling with the last corner of this crossword. I`m sure if I can solve these two clues it would help enormously.

18 ac Jack rings after disease-germ had become cause for anxiety (7) - - G - - O O

13 d Twice exclude unknown copy of macaque (7,3)
- A - - - - - A-E

thank you

13 Down is BARBARY APE

Bug + AB (Jack) + oo = bugaboo?

18A May be Bugaboo. Germ = Bug
BOO - could cause anxiety

Could be that, but not sure what the definition would be if "cause for anxiety" is Boo, and why rings and Jack?