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8A Complaints as doctor breaks key laws (8)
?R???L?S
2D no-win situation besetting mass publication (5)
T???S
22A Mischievous young woman finally detonating an explosive device (6)
?A?I?E

first one is G RU(MB)LES

22, G a mine.

22 Gamine

2, Ti m es?

Thanks I figured MINE but GAMINE is a new word for me - (just looked it up) and should have had GRUMBLES

So T?M?S for 2D - not many options on Chambers Word Wizard but having a senior moment and cannot make any fit!

Got it now TIES pls M - that is it time to see how Federer is doing v Del Potro then Chelsea Man C - another sporting weekend.