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16a person obsessed with one issue (10)
2d lasting a short time (9) t?m??????
35a invasive quality (13) I????????e????
5a roomy (9)
56a chemical building block (7)
55a lead an attack (9)
And finally (for now!)
8d leave someone far behind (11). ??t?i??????

16 monomaniac?
2 TEMPORARY

Monomaniac
Temporary
Intrusiveness
Capacious
Element
Spearhead
Outdistance

monomaniac
temporary
intrusiveness
capacious
element
spearhead
outdistance

I'm stuck on 41d spontaneously create (9) i?t?n?i?e
think I may have a mistake in there somewhere

Improvise

Thanks jazzgirl just got it myself, had RYTON instead of RIPON and REGRESSING instead of REGRESSION! Just need to complete the shortie now!

Thanks for all your help