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Much better than last week's - now stuck on the last two :
54A - Intruder does worry about having entered home before (9)
I?T???E?E
&
52D - Chief mostly is stiffly formal (4)
???M

I like to think the letters supplied are correct.......

54. Interfere

prim[e]

Worry: fret (reversed)
Home: in
Before: ere

Thanks to Jazzgirl & Ixion for both answers & especially to the former for explaining quite why it was Interfere as opposed to the other half a dozen "inter...." answers between which I dithered.

Time for bed with a stiff biography & a similar single malt.......