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Stuck on 3 clues! 18a (12,9) Children`s game, 21d(7) Coiled thread in cell division;premise(ang) and 42d (9) Get rid of

21d is SPIREME - see:
http://www.thefreedictionary.com/spireme
I must say that I studied cell division as a part of a Genetics course, and have never heard of it!

Have you any letters at all?

Thanks Chrise ! Yes I have 18a G?A?D?N?H?R?,F?O?S?E?S and 42d E?I?I?A?E Sorry

18 Grandfathers Footsteps or Grandmothers Footsteps.

18 check the N - I don't think it's right!

eliminate?

42 Eliminate (if your first 'i' is correct) or Eradicate (if it isn't!)

Thanks for spireme Chrise! I am a science teacher and have never used that word in cell division! Also stuck with children's game and 11D - problem solving beginning with T (15) Any help much appreciated!

Grandmothers footstseps
Troubleshooting