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Thanks to you all, yes, the N in 18a/5d was wrong ! Now finished thanks to you people, off to the Theatre at 1.30 just in time !

I have eliminate as it fits with 44A "travel broadens the mind"

Thanks Jazzgirl! While you are out there could you please help with 2D twisting, making someone out of breath (7) and 25A humorous through perverse contrariness (6)

Winding
Ironic

Thanks again JG! What would we all do without your brain!

Spireme is the coiled filament in cell division

Thanks liverpoollass- dont suppose you have 29d do you? I think that I must have gone wrong somewhere - I have ?r?d?s?o?i?i?n Any pointers you could give would be greatly appreciated.

oops sorry forgot to give the clue- An already exisiting incination.

I struggled on this one - predisposition

Thank you robinp. It was my last one and, cos I couldn't work it out, I thought that I must have gone badly wrong somewhere!