???i???i?? - 10 letter crossword answer

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Irritating

verb - (used of physical stimuli) serving to stimulate or excite; "an irritative agent"
cause annoyance in; disturb, especially by minor irritations;
causing irritation or annoyance; "tapping an annoying rhythm on his glass with his fork"; "aircraft noise is particularly bothersome near the airport"; "found it galling to have to ask permission"; "an irritating delay"; "nettlesome paperwork"; "a pesky mosquito"; "swarms of pestering gnats"; "a plaguey newfangled safety catch"; "a teasing and persistent thought annoyed him"; "a vexatious child"; "it is vexing to have to admit you are wrong"
causing physical discomfort; "bites of black flies are more than irritating; they can be very painful"
excite to an abnormal condition, or chafe or inflame; "Aspirin irritates my stomach"
excite to some characteristic action or condition, such as motion, contraction, or nervous impulse, by the application of a stimulus; "irritate the glands of a leaf"

Irritation

noun - (pathology) abnormal sensitivity to stimulation; "any food produced irritation of the stomach"
a sudden outburst of anger; "his temper sparked like damp firewood"
an uncomfortable feeling of mental painfulness or distress
the act of troubling or annoying someone
the neural or electrical arousal of an organ or muscle or gland
the psychological state of being irritated or annoyed
unfriendly behavior that causes anger or resentment

Irritative