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First hit? Losing feeling just after taking drug (3)
Def ->First
Hit-> number 1.
losing feeling -> subtract “number”
Just after-> On ( definition 18 in Chambers)
Drug-> E

gave it a double construction for better surface

Only naked singer comes back (3)

t(eno)r

Loudly triumphed 2-1 (3)

Vaguely topical

0 + 0 - 0 = 0! (3)

(O + NONE - NO, 0!=1)

Opening number in Indonesia (3)

Prime number? No, strangely, yet essentially unique (3)

Proton-electron interaction complete (3)

I'm set in stone (3)

Nero has no right to appear unique (3)

Enron went bust and lost the right to uniqueness ||||(3)