I'm in agreement with you, gitto, about 22d; it should have had a "that". In the case of 33d I feel that the Chambers definition is faulty in not indicating the main application of this answer but working with Chambers is the setter's responsibility.
On the other hand I have no problem with the clues for 42a and 35a except that in the latter the word order is a little odd.
With regard to 2d and 15a, whether they're acceptable or not depends on how much the setter can assume the solver knows about major figures in their fields in the 20th century.