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25 ac must be “Top Secret” (highly sensitive), but how does it fit the rest of the clue? Is the fact that “top secret” is almost an anagram of “retrospect” relevant?

It would help if you gave the clue!

Hello, Tim. It's always better to give the whole clue - not everyone has a copy, so it's a bit difficult to help!

Phrase defined by cryptic part of clues is then reversed to get the answer

Sorry, I assumed anyone reading this would have access to the crossword and the clues. The clue was: “Highly sensitive time for prayer, situation that’s awkward in retrospect” (3-6).

Thanks, Tim.

Time for prayer - Terce (oneof those churchy terms, like Nones)

Situation that's awkward - Spot

In retrospect, reverse both bits - Tops ecret.