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50D - Just after suffering odd losses, jump down (4) U?O?
Not sure about the O though. Cannot believe I can't solve a 4 letter clue!

UPON (even letters in jump down having lost odd lettrers)

Thanks for that. I did think of UPON but couldn't parse it - I can see it now though.

Completely ground to a halt now. Can anyone please help with the following:
56a Native American turning machine into a craze
?L?T?E?D
9a Capital area with passports once shown for screening
????I?O
27d Grasping grand covered in damp grass?
?R?E?E
Any or all of the letters I have may be wrong!

27d Grasping grand covered in damp grass?
?R?E?E
Answer is GREEDY
Greedy=grasping; G=grand; reedy=covered in damp grass

Thanks Cannyannie, that final E confused me. Back to the drawing board with 39a

9a Pimlico (after the film screened 1949 "Passport to Pimlico"
56 flathead (Native american)

lathe in fac

typo: lathe in fad

Thanks jazzgirl. Flathead came up as an option but the definition was a sort of fish!

Yes, also a fish ;)