cause annoyance in; disturb, especially by minor irritations;
aroused to impatience or anger; "made an irritated gesture"; "feeling nettled from the constant teasing"; "peeved about being left out"; "felt really pissed at her snootiness"; "riled no end by his lies"; "roiled by the delay"
roused to anger; "stayed huffy a good while"- Mark Twain; "she gets mad when you wake her up so early"; "mad at his friend"; "sore over a remark"
an open skin infection
hurting; "the tender spot on his jaw"
causing misery or pain or distress; "it was a sore trial to him"; "the painful process of growing up"