Hi xwordfan,
10d 3 letter word for punch (tool) + 4 letter word to describe strong alcohol (or drugs).
12a. Yes. 2 letter abbreviation for men and 4 letter sounds like a European.
think 10d is diehard and 12a is ordain
you're ahead of me - stuck on left side
gtfl help 2d Miserable Mo missing a supply of tea? (6) ??N?U? and 42a Global pharmaceutist a vivacity imbues (6) ??I?E?
Thanks ginge ... already had that for 12a and wasn't really convinced! Rather like some more of my answers (which are correct but I have yet to parse some of them!!)