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I have completed the grid and made 12 alterations, but I am not sure about my 2d and 10a. Is 10a a physics abbreviation?

Thanks guys...23A makes perfect sense now.

10A is an abbreviation, it's in Chambers

2D word for pain about word for sick and one other letter...

I think the 12 clues that must be changed are:

8,11,12,14,25,2,3,13,18,19,21,22

ixion: 1D not 2D

2d double defn piercing and cry, then change its last letter as preamble states

Thank you - I have found the appropriate word for 2d now! I had miscounted my 12 corrections.

What are your collective thoughts about P and N?

It occurred to me that you cannot go from "+" to "-" (or vice versa) if you remove (add) an electron. For instance, if a "+" captures an electron, the result is neutral (no electric charge). Similarly, if a "-" loses an electron (by decay), the result is again neutral.

So, my theory is that N is for Neutral, and P for Positive.