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Am getting there but stuck on 3down. Half-hearted insignificant people,according to them?(5) SCO??.

I think Dora? may be 'Do right angle'

I have SCO?S (the "s" came from preSIDE - pairs up with 11d) so I suppose it must be SCOTS, but I don't know why?

scoot or scout can mean insignificant so SCOTS would fit the clue

Thanks. I'm done now!

Yes - harder than recent speccies with some tricky clues!

42 A. Topping sedative drugs with an unknown cure (6) ?e???y
I want to put 'remedy' (cure), but can't see how it fits with the rest of the clue.
22 A. Good moment for employees including a bit of long-awaited time off (7,hyphenated)
?l?????
Would appreciate any kind of help. Thanks

22a is P(L)AYDAY!Don't u'stand REMEDY either.And,last of all,just can't get the pair 24a/18d:have SA???US and ?A??R.Oh,and if 28d is RESIGNS,what is the 3rd letter of 36a?Many thanks in advance to anyone.

20 A. Blame for Glaswegians,reportedly innocent (4) ??te
My knowledge of Scottish words is non-existent!

Made a wild guess at 20 Across, and it turned out to be a word/the word.