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16 A. Almost baffled by English writer on religion of 16C. (4) -o-e

Foxe(d)?

Still mulling over 13 Across.
Small numbers with horse disease as before (5) -ives
I know that 'vives' is a horse disease, but wondered what the 'as before' refers to - could it be the 5 in (5)?So maybe the answer should be 'fives'?

Chambers Dictionary gives FIVES (Shakesp) same as vives.

I reckon the answer is FIVES which was VIVES in Shakespeare's day - ie "as before"

How does the cryptic answer for XENICAL work please? (Clue was "Doctor buys this drug? Could be inexcusably")
2d splAts?

INEXCUSABLY is an anagram of XENICAL and BUYS,
"Doctor" indicates the anagram.

Thank you Boltonian - any thoughts on 2d?

Take Busy out of inexcusably and rearrange?

I haven't completely worked out the clue apart from the ALPS being "up" so it must be SPLATS