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Just stuck on 2 clues.
52d - Popular novelist doesn't stop interfering with books?
I have C-O-S-N.
45a - Boy needs mum:is that unusual?
I have M-T-H-A-.
Any help gratefully received.

Sorry that should be 52across of course.

45A MATTHIAS

45 Matthias
anagram: Ma + is that

52d Cookson
cooks on (doesn't stop interfering with books)

45, Cookson.

Novelist is Catherine Cookson

Am I the only halfwit finding this week's very difficult?

I have struggled, with considerable difficulty, to the point where I'm stuck on 5; help with the three below may spur me on :

3D - Tips for office job: do no donkey-work and no paperwork? (5)
E???K
22D - Yanks holding Republican line in mess (8)
???L?C?S
&
47A - Impracticable cunning failed to get a hearing (4-4)
?I?D-?Y?D

I'm just hoping that if this one is difficult, tomorrow's will be a cinch.....

3d E-BOOK
tips(end letters of) office job do no donkeky-work)

47 Wild Eyed, impracticable - sounds like Wile, cunning, Died, failed.

22 Horlicks, a mess. Hoicks, yanks (not capital) with R, Republican and L, line.