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Any help would be much appreciated with today's jumbo crossword:

42 ac - kind of sharp tasting tonic (9, 7) A-G-S--- -I---R-

53 ac - lack of exactness (11) ??P?E???I?N

23 down - Ringing sound (16) ?I?T?N?????A???N

42a angostura bitters

53a imprecision

23d tintinnabulation