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Right .... if someone can just help me with 2d, I should be able to finish the top left corner! As it stands, all I've got for the clue "Very small thing - to us, impracticable sadly" 9,8. is C for the last letter of first word, and ???T?O?E for the second.

subatomic particle
anagram of "to us impracticable"

Thanks, elle. Perhaps I can get going again now.

You're welcome, duckb.
Glad I could help!