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each clue has a single letter misprint in the defn
33a Welsh corgi finally runs into field spreading a disease of some dogs (5) R????
39a Hairy vagrant accepted in hotel (8) I???????
43a Bill of sale covering pulleys out of Thailand now having a rear part (7) S??LE??

Also : 21d Mature European off the straight for home A?E? ... must be AGEE = off the straight ?? misprint in home?

25a Belgian detective's facing scowling South American monster? Must be Hercules beetle but too many letters ?? Do the E and the S go in the same cell?

33a wildfire
39a iolanthe
43a backless

21d misprint is Some for home
Hercules beetle is correct- look at the down clue and see what letters clash. There are a different number of letters in the various clashes around the grid.

thanks - will work on those