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I need help with the final two clues please.
21a. Note positive response of viewers. (4) E _ E _. Possibly Eyes?
23d. The suggestion has come up that it is near bedlam. (6). _ R _ S _ N. Possibly Prison or Arisen?

eyes is correct - E the note+ yes

note - E (music). positive response - yes. viewers - eyes.
23d anagram of ' is near'.

arisen -anagram of 'is near'

I thank you both very much!