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5. Across Look and sound a match for (6) ?P???R

4. Down Why the case to be opened up is out (5) ??H?R

The fourth letter of 5 across is the first letter of 4 down.
Thank you in anticipation

appear - sounds like a peer?
total guess - ether.

5 APPEAR

5. Across Look and sound a match for (6) ?P???R
Appear?

ETHER looks OK, Trevor - anaesthetic used before an operation?

Thank you all!

...of course chris, the case being the patient.

i sound a bit smug there, i meant thank you, i didn't really see it.