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Really stuck on these four.
16a. (4) house surgeon holds applications. - - - s (is it uses)
22a. Trendy company's failing (6) - - - i - m

17d. Country cool after spring - - a - - (5)

19d. Penny contributions, or where they are held (5)
P - l - s

16 yes - in clue
22 In firm
17 Spa in

19d palms

p alms

Many thanks to Scorpio, chiffon and bigbadmarty2.