You could start with 4dn/19dn, but that won't help you enter anything in the grid immediately. 1 dn has only 2 possible entries, all the other options being 4 digits. One of those is quickly eliminated by considering 6 across.
Another useful clue is 20ac, which has only one answer that yields a 4-digit product with a 3-digit entry, so you can enter three digits in the grid without waiting for any crossing confirmation.