Maybe some of the crossing clues might help:
1. Haunting music from university players (5) ? ? ? E ?
2. Out of line, yet nothing to stare at (3) ? ? ?
3. How sin comes from sign of illness (4) ? ? ? T
While a spot is "a blemish on the character of a person; moral flaw" and therefore "how sin comes" and spot is also a sign of illness, it seems a bit thin.....