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21a Make permanent address(4,6,6)
?a?y ?o?e?s ?o?k?r

40a Where knickers manufacturers might invest as firm(9)
??e???tic

inelastic?

davy Jones's locker fits but i can't see why.

21a Main permanent address(4,6,6)

Main = the sea

Thanks for inelastic. I had just got Davy Jones's locker before you replied with that one.
What about 40d Couple hugging time after time after time after time, then on for doing it again(9)
i?e???I??

ta Mamya, i suspected something might be wrong with the given clue - damn auto text correct thingies!

iteration.

Thanks Trevor

Is 56a "Make no mileage"
Clue is: You can be certain to get things 100% right? (4,2,7)

54a Something from mum, a mighty meaty taste(5)
i?a?i

umami
from m[um, a mi]ghty