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Clue is Cause of great suffering (11)

I've got T*I*C*A*I*N
but for life of me can't see what it is. Inspiration anyone please?
Thanks.

Are you sure the 'c' is correct? The answer looks like Tribulation.

I thought so. the C came from 16 A, sugar and honey sweet which I had as nectar...............
light bulb moment - it should be nougat then that puts the T where is needs to be

thank you Chips for giving my brain cell its much needed kick :)