Hi Ros; been at this 20 mins; think I've found the first important key. Using the terms A-I for the squares and 1-9 for the small squares; Since E7=7 and E8=1,2 or 4, sum B8+B9 = 12,13, or 15.
Therefore Total A+B (- B2+B3) = 83, 84, 86
B2 and B3 can only be 1,2 or 4. So sum B8+B9
CANNOT be 12 (B2+B3 can't be 7) and CANNOT be 15 (B2 +B3 can't be 4) so MUST be 13.
More work to do, though! Got to go out now. Good luck!