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26 across:for silver in large quantity, one's beginning to transmute lead (11): P-o-a-o-i-n but cannot find a word to fit so perhaps some letters wrong. explanation and help please

Protagonist (the lead in a film,play whatever).
I'm hopeless at explaining, so I won't even try - sorry!

Protagonist.

protagonist
for - pro
silver - ag
ag in ton - large amount
ones - is
T(ransmute).

Many thanks Trevor, Rusty and Malone. Perfect!