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10A school subject,in short (3) B??
11A washes or bathes (5) L?V?S
41A a twitter update (5) T????
4D itaian Lake (4) C//R
27D Extinguishes fire by covering it with ashes etc (8) SM?T????
33D prickly desert plant (6) ?A???S
39D study hard and hurrirdly (4) S??T

I thank all those who are going to respond

41A tweet
27D smothers

39D swot

33D cactus

11A laves
4 D - Como (perhaps you have a letter wrong?)
33D cactus

The last is BIO (= biology at school)

I thank you DAVE,HARPIST and BRACKENDALE