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Cryptic. 21a Refuse in study close to trolley. (4) d - n -

Easy. 9a. Constant preoccupation (13)
- - s - - - - - - - e - s
The fifth last letter is possibly an 'e' or an'n'
10a Cargo - - - - - - - - (8)
3d. Combo e - - - - - l - (8)

22a. Inept. (4-9) - - - - o - d - n - t -

first two are DENY and OBSESSIVENESS.

combo = ensemble

Thank you that gives Cargo, - - - - m - - -

SHIPMENT perhaps

22A uncoordinated (4,9!?) it's the only thing I can think of that fits with the clue inept