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19 D. Suffering local epidemic,affected zone quickly picked up (8) e?s?o???
25 D. Famous actor's eccentricity to be very obvious (5) ?t???
Thankss for any help of any kind.

1st; only word that fits seems to be ENSCONCE but can't see how this fits the clue!

2nd; STARE?

Obvious could be stark, although I'm not sure where the k comes from.

Hey Sal; long time no speak, you OK?

Hi paul, not too bad at the moment, still breathing! ;0) How are you?

Good thanks, still somewhat sleep deprived! Glad to see everything's calmed down on the forum!

Yes, it's pleasant. how's the baby and of course your wife! Oh and apologies Chips for going off subject!

19. Enzootic - Anagram of Zone + Cito

Talia is a bright spark! Less than 2 months and gurgling, smiling, loves interacting and attention (must be a typical Leo...)
Lucy has been through the ropes though, what with mastitis (twice) and other stuff. Oops, must add my apologies to Chips for tangential observations!

Brilliant answer BlueIce