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Stuck... help please.
1 A room on board gets loud - always the effect of isolation (5,5)

77a Such art makes the state turn in (6)
121 One who tries on a 24 across (slipper) riles Gusty somehow.(4,6)

Hi.

1. cabin fever.

JimC

Hi again.

121 ugly sister (anagram).

JimC

77a STATUE

State with U turn in

Thank you so much, my brain a bit frozen this morning.