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29a) Producer of Death Wish had not sat out director's initial cut (8) T-A---O-.
'Death Wish' is in italics.
21d) Mischief-maker restricts almost all of movement that's slow in general (2-5) --/--r-e.
22d) At work, nurse's 1 dn (6)---E-D. (attend?)
25a) Happy and carefree loved one packs lacy pants (7) H---Y--.

25a) Happy and carefree loved one packs lacy pants (7) HALCYON

29a) Producer of Death Wish had not sat out director's initial cut (8) THANATOS.

21 down is 'at large' (the goddess Ate, a bit of a joker, around larg[o]) but I'd really appreciate some explanation of 22 down - what is the reference to 1 down all about?

times 24718 Hi-a rare use of DESIGN means INTEND and vice versa!!!!