Below are possible answers for the crossword clue Of great significance.
9 letter answer(s) to of great significance
MOMENTOUS
of very great significance; "deciding to drop the atom bomb was a very big decision"; "a momentous event"
10 letter answer(s) to of great significance
PORTENTOUS
boding
of momentous or ominous significance; "such a portentous...monster raised all my curiosity"- Herman Melville; "a prodigious vision"
Ominous fateful
ominously prophetic
puffed up with vanity; "a grandiloquent and boastful manner"; "overblown oratory"; "a pompous speech"; "pseudo-scientific gobbledygook and pontifical hooey"- Newsweek
Other crossword clues with similar answers to 'Of great significance'